A new transgene reporter for in vivo magnetic resonance imaging

The ability to image the gene expression in vivo is important for biological and medical studies, especially in a non-invasive manner. To indicate where and when the therapeutic gene goes is a very crucial step in genetically medical applications. Magnetic resonance imaging (MRI) is a widely used diagnostic tool. It is not invasive, and it provides a good spatial resolution. More importantly, it allows us to view into the opaque subjects.

Therefore, the novel transgene reporter for MRI application in vivo is important because this technology can be used to monitor the gene expression in many kinds of tissues and it is optimal for medical applications such as visualizing preclinical therapeutic gene delivery. By using a vector that encodes a superparamegnetic metalloprotein to introduce the MRI reporter gene into hosts, we can easily monitor the gene expression in a living organism.

Hui-wen Lin
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