Lymphocytic leukemia and epigenetic

As we know, chronic lymphocyte leukemia is a form of leukemia which is the most common form of leukemia in the western countries. It mainly affects people over the age of 50. Patients with CLL are divided into 3 gropes: If the deletion happened at chromosome 13q14, they will have a big chance to survive whereas potions with deletions at chromosomes 11q22-23 and 17p13 will associate with an adverse outcome and finally if the deletion and the mutation happened to the p53 gene, they will have a poor chance to survive.
In human cancer, many interactions between DNA methylene, histone modifications and RNA interference have been implicated. In this research, they used a candidate gene approach to determine the methylation status of 15 cancer-related genes in 32 potions with CLL. And they found that methylation patterns in CLL are disease s-specific, this because that the profile is not similar to other hematopoietic malignancies.


Zainab Almansour
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