PERMANENTLY ALTERATION TO THE DNA METHYLATION OF SPECIFIC CYTOSINES

Post by Shahril Asraf Omar,41858893
Do you aware the aspects of prenatal environment? Do you believe nutrition will alter the phenotype persistently? How the environment and nutrition affect the way mammalian genes?
There is a high possibility that environmental factors could catapult changes at
levels than the genetic information and thus give huge impacts as well. DNA methylation and covalent histone modifications are two important parts which
monitor or control gene regulation could be interfered by environmental and diet factors.
Protein-restricted diet increases glucocorticoid receptor (GR) and PPARα expressionin the liver by inducing hypomethylation and decreases DNA methyltransferase-1 expression. However, by increasing folic acid content could prevent hypomethylation. DNA methyltransferase-1 expression in human umbilical cord is strongly associated with methylation of the GR promoter. The promoter regions of many genes consists several CpG dinucleotides at which caused changes in methylation.