Histone modifications silence the GATA transcription factor genes in ovarian cancer
Article: Histone modifications silence the GATA transcription factor genes in ovarian cancer
C Caslini, C D Capo-chichi, I H Roland, E Nicolas, A T Yeung and X-X Xu (2006) 1-16.
GATA transcription factor genes are important for lineage determination during development. Loss/ absence of GATA 4 and GATA 6 lead to loss of the expression of its transcriptional target such as tumor suppressor gene Disable-2, Dab 2, which has been found in ovarian cancer.
Caslini et al. believed that the mechanism pathways of other cancers are different than in ovarian cancer, although the mechanism is still not clear.
In this study, they indicated that the alternation of chromatin conformation, including the hypoacetylation and histone H3 and H4 and the decrease of reduction in di- and tri methylation of H3 lysine 4 play a critical role in silencing the GATA 4 and GATA 6 in five ovarian epithelial and carinoma cell lines HIO-117, HIO-114, A2780, SKOV3 and ES2).
Takyan
C Caslini, C D Capo-chichi, I H Roland, E Nicolas, A T Yeung and X-X Xu (2006) 1-16.
GATA transcription factor genes are important for lineage determination during development. Loss/ absence of GATA 4 and GATA 6 lead to loss of the expression of its transcriptional target such as tumor suppressor gene Disable-2, Dab 2, which has been found in ovarian cancer.
Caslini et al. believed that the mechanism pathways of other cancers are different than in ovarian cancer, although the mechanism is still not clear.
In this study, they indicated that the alternation of chromatin conformation, including the hypoacetylation and histone H3 and H4 and the decrease of reduction in di- and tri methylation of H3 lysine 4 play a critical role in silencing the GATA 4 and GATA 6 in five ovarian epithelial and carinoma cell lines HIO-117, HIO-114, A2780, SKOV3 and ES2).
Takyan
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