Regulation of adult olfactory neurogenesis by insulin-like growth factor-I
The human nervous system is a stupendous piece of biological machinery. The treat of neurological impairment evokes a special dread. Damage to the spinal cord can create equal misery in just an instant.
For many years spinal cord injury has been seen as clinically irreversible, although many attempts have been made in animals to regeneration the spinal cord using a variety of transplanted cell types. Fortunately, significant process has been made recently with olfactory ensheathing cell's transplantation in injured spinal cord.
The article "Regulation of adult olfactory neurogenesis by insulin-like growth factor-I" (European Journal of Neuroscience, Vol. 22, pp. 1581–1588, 2005) investigate the roles of insulin-like growth factor-I (IGF-I) in regulating proliferation and differentiation in the olfactory mucosa. The action of IGF-I was assayed in serum-free culture combined with bromodeoxyuridine-labelling of proliferating cells and immunochemistry for specific cell types, as well as IGF-I and its receptor were expressed by the neuronal precursor and by olfactory neurons. It showed that IGF-I reduced the numbers of proliferating neuronal precursors, induced their differentiation into neurons and promoted morphological differentiation of neurons. The evidence suggests that IGF-I is an autocrine and ⁄ or paracrine signal that induces neuronal precursors to differentiate into olfactory sensory neurons.
It is hoped that one day, the transplanting of special olfactory glial ensheathing cells from the patient's own nose into the damaged spinal enable damaged spinal tissue to repair itself, and I'm sure of that day's coming.
Ying Wang
For many years spinal cord injury has been seen as clinically irreversible, although many attempts have been made in animals to regeneration the spinal cord using a variety of transplanted cell types. Fortunately, significant process has been made recently with olfactory ensheathing cell's transplantation in injured spinal cord.
The article "Regulation of adult olfactory neurogenesis by insulin-like growth factor-I" (European Journal of Neuroscience, Vol. 22, pp. 1581–1588, 2005) investigate the roles of insulin-like growth factor-I (IGF-I) in regulating proliferation and differentiation in the olfactory mucosa. The action of IGF-I was assayed in serum-free culture combined with bromodeoxyuridine-labelling of proliferating cells and immunochemistry for specific cell types, as well as IGF-I and its receptor were expressed by the neuronal precursor and by olfactory neurons. It showed that IGF-I reduced the numbers of proliferating neuronal precursors, induced their differentiation into neurons and promoted morphological differentiation of neurons. The evidence suggests that IGF-I is an autocrine and ⁄ or paracrine signal that induces neuronal precursors to differentiate into olfactory sensory neurons.
It is hoped that one day, the transplanting of special olfactory glial ensheathing cells from the patient's own nose into the damaged spinal enable damaged spinal tissue to repair itself, and I'm sure of that day's coming.
Ying Wang
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