Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically

Are you fond of tipple? Do you have any relatives or friends who are really crazy about liquor? Please drink less and request them to drink less. It is universally acknowledged that people who usually consume alcohol are easy to get their liver injuried. Do you know the reason why this phenomenon happens?
Joan Oliva and her colleagues did an experiment about rats that fed ethanol chronically and discovered something that was related to alcoholic liver disease. They demonstrated that chronic ethanol feeding has some connection with an increase in histone acetylation and found out what is the role of proteasome inhibition in the regulation of epigenetic mechanisms of rats. If you want to know more details about this, please visit the following website:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2653439
After you reading this paper, you would able to persuade your family and friends to enjoy less ethanol. Although their just did an experiment on rats, it may be a promising and smart method to study and research liver injury due to chronic ethanol consumption.

Oliva,J.,Dedes,Je.,Li,J.,French,S.W.&Bardag-Gorce,F.2009,Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronically.World Journal of Gastroenterology ,15(6): 705-712.

Qiushi Chen
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