SATB1 IN BREAST CANCER EPIGENOME

SATB1 is a special AT-rich binding protein known as a nuclear organizer for the development of tumour cells and promoted metastasis. The study of Han et al on "SATB1 reprogrames gene expression to promote breast tumour growth and metastasis" disclosed that SATB1 is a key factor in breast cancer progression due to to its ability in regulating gene expression via chromatin remodelling. Both invitro and invivo methods were used to test for the function of this protein in breast cancer development. The results in this study showed that SATB1 acts as an activator for the promotion of aggressive cancer phenotypes and metastasis. Key epigenetic progress for this tumour progression is the formation of chromatin loop for transcription process resulting in targeting chromatin remodelling and regulating histone modification.

Han, HJ., Russo, J., Kohwi, Y. & Kohwi-Shigematsu, T. (2008). SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature. 452:187-193

Dinh Hoang Lan Chi,
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