The c-MYC Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis

c-M YC is a family member of transforming genes such as n-MYC and l-MYC.

c-MYC oncogene products in many cancers (breast, lung and fibroblasts) are deregulated and function as regulators of genes transcription.

c-MYC induces the expression of noncoding RNA H19 by binding to the conserved E-box near the imprinting region.

On the contrast it can repress gene transcription by interfering with the function and assemblely mechanism .

As a regulator its involved many gene target that would eventually implement its various biological executions e.g. a apoptosis , cells proliferation etc

c-MYC down regulates the expression of insulin-like growth factor 2 (IGF2), the imprinted gene at H19/IGF2 locus

Finding the genes Target is the main objective in explaining the mechanism of this oncogene in transformation and has attracted the attention of this study

By Solomon Alier