link between NNK and induces DNMT1

This study provides an explanation between the compounds found in cigarette or what is known as NNK ( nicotine ,nitrosamine and ketone) and the lung cancer, and what is the main causes to make NNK increase DNMT1 protein expression and activity? It also shed the light on over expression of DNMT1 protein stability through AKT signalling. It besides trigger off AKT then inhibits GSK3β/β-transducin repeat (include protein) mediated protein degradation, and the result DNMT1 protein accumulation.
It can be reason out that the conclusions made in this study are highly pertinent to the study of other Kind of cancer. It can be reason out that the conclusions made in this study are highly pertinent to the study of other Kind of cancer. The results showed assertions of this research provide an invaluable perspective in tumour and cancer research as well as studies on other types of human disease. It also opens up probability for developing better Means in improving prognosis in clinical manifestation of related epigenetic disorders that lead to these diseases.

Ahmad Baqazi

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