Long non coding RNAs have an important regulation role in embryonic stem cells
Ayrú Alejandra Rojas. Student number 41873252

Embryonic stem (ES) cells are those derived from the inner mass of the blastocyst, in the early stages of embryo development, and are capable of differentiating into most adult-type lineage-specific cells. Given this property, these cells are able to repair and renew damaged tissues and genetically defective adult organs. For this reason, is necessary to understand the fundamental processes which are essential for the maintenance of pluripotency. In a recent study it has been demonstrated that long non-coding RNAs (ncRNAs) with 200 or more nucleotides, are present thousands of times in the genome of mammalian species, and apparently are involved in the biology and development of embryonic stem cells. These investigators, showed a number of ncRNA which showed a high correlation with well recognized developmental genes, in several stages of ES cells. Additionally, evidence was given, to prove an association between long ncRNAS and trymethylated histones and histones methyltransferase, suggesting a function involving epigenetic regulation.

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